Evidence for Long-Term Neurotoxicity Associated with Methamphetamine Use in Humans: A Proton MRS Study
نویسندگان
چکیده
Background: Methamphetamine abuse is a reemerging epidemic in the United States and in many Asian countries. Clinical and preclinical observations suggest that methamphetamine may cause longlasting injury to the brain. In humans, some of the psychiatric conditions, such as paranoid psychosis, may occur not only acutely during methamphetamine exposure, but may persist for months or even years after cessation of methamphetamine use (1, 2). In rodents, methamphetamine is toxic to dopaminergic and serotonergic neurons (3-5). However, little biological data is available on the possible toxic effects of methamphetamine on the human brain.
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